Browse every published article, from the latest research to earlier analysis. Use the page numbers below to explore the complete archive.
A report that mentions diazepam-binding inhibitor may sound like a report of diazepam in serum. The name refers to an endogenous protein, also called acyl-CoA-binding protein or ACBP. The analyte listed on the test is what determines the interpretation.
A significant result across three groups can show that the data warrant closer inspection. It cannot tell a toxicologist which specific feed caused a difference without an appropriate follow-up comparison.
A laboratory can measure several drugs in a single chromatographic run. Each drug still needs a calibration range that covers the concentrations the assay is intended to report.
Two samples can fall on different parts of the curve A report of a mixed oral overdose documented a plasma duloxetine concentration of 57 ng/mL in a specimen taken during ambulance transport and 126 ng/mL approximately 32 hours after ingestion. Other drugs were also involved. The authors compared the measured concentrations with simulations from a…
A faster run can also change analytical performance The study compared high-performance liquid chromatography with an ultra-high-performance implementation for seven benzodiazepines. The reported run time fell from 40 to 15 minutes. The systems also used different column particle sizes, operating pressures, flow rates and injection volumes. The instrument label cannot supply the reporting limit The…
The study used separate probes for separate pathways Garg and colleagues studied interactions involving tezacaftor and ivacaftor in healthy participants. In one set of comparisons, midazolam served as a probe for CYP3A metabolism and digoxin served as a probe for the transporter P-glycoprotein. The researchers measured systemic exposure to see whether the combination affected each…
The design separated cells from their surroundings Acikgöz and colleagues exposed cultured primary human and pig hepatocytes to diazepam. They separately analyzed the cell material and the liquid above the cells. That design allowed them to compare what remained in the cellular compartment with what appeared in the surrounding medium. The sampling compartment changes the…
Two compounds in one solid Valenti and colleagues made mixtures of diazepam and nordazepam and mapped their melting behavior across compositions. The eutectic, or lowest-melting composition, was approximately 18 mole percent nordazepam, with a melting temperature near 395 K. The authors also melted and cooled mixtures to study the resulting noncrystalline material. A stable glass…
Follow the measurement across development Nguyen and colleagues used a rat model of repeated neonatal midazolam exposure and examined outcomes at several developmental stages. The authors measured neurotransmitters in the prefrontal cortex alongside molecular and behavioral outcomes. Looking across ages allowed the group to ask whether an observed difference persisted or changed direction. The findings…
The formulation was the variable Nishioka and colleagues compared ordinary midazolam solution with two liposomal preparations, one with a polyethylene glycol (PEG) coating and one without. They characterized the particles, administered the preparations to rabbits and measured plasma midazolam. A formulation change can alter exposure even when the active drug has the same name. Exposure…
A modeled concentration and a dose delivered over time can both describe a sedative requirement, but they have different units and answer different questions.
An intensive-care study used oxygen consumption and carbon dioxide production to estimate resting energy expenditure at several sedation depths. The investigators measured metabolic activity and assigned sedation scores as separate steps.
An estimated dose can look precise when stated to two decimal places. In a dose-finding study, the part of the response curve being estimated matters more than the formatting of the number.
A change in plasma midazolam after an oral dose can begin before the drug reaches the liver. A mouse experiment with the herbal formula Banha-sasim-tang separated that possibility from the assumption that every oral midazolam change reflects CYP3A activity.
The case report followed concentrations around treatment The team used the Molecular Adsorbents Recirculating System, an albumin dialysis system, in a patient with prolonged severe intoxication after reported diazepam ingestion. The first session was followed by a decline in the reported plasma benzodiazepine concentration from 1,772 to 780 micrograms per liter. Five sessions were performed.…
A 10-person study illustrates why a fixed psilocybin dose can yield a wide range of peak plasma psilocin concentrations.
A neuropathic pain experiment used an instrumented gelatin dispenser to track when mice consumed cannabinoids.
A blood microsampling method used enzymatic hydrolysis before measuring CBD, THC and metabolites.
A published LC-MS/MS method used 50 microliters of serum or saliva to measure CBD and an active metabolite.
A small canine study compared CBD oil given by mouth with the same oil given across the oral mucosa.
An Australian survey asked medical cannabis users about driving after use. Learn what its 28% figure measures and how it differs from evidence of impairment.
A crossover simulator study tested whether equal CBD content changed lane tracking after THC.
A published HPLC validation illustrates why the sample type and the laboratory method matter when reviewing a THC result.
A matched study compared scalp hair cannabinoid concentrations in patients with and without cannabis hyperemesis.
A single-participant smoking study illustrates why the THC content of CBD-rich flower matters when interpreting urine results.
A study in 13 volunteers measured four CBD metabolites after a cannabis decoction and oil.
A canine study tested for CBDA and THCA alongside CBD, THC and selected metabolites.
A higher peak on an ankle monitor can reflect more than a larger reported alcohol dose. In a 2021 study of 43 people, Richards and colleagues examined 183 drinking days that SCRAM detected. They compared the recorded peak and area under the transdermal alcohol curve with reported drink counts and participant characteristics. Peak and area…
Killian and colleagues paired smartphone accelerometer readings with ankle-monitor readings in a field dataset from 13 participants. They divided the motion data into short windows and trained a model to classify those windows using a transdermal alcohol threshold. The label depended on a sensor and a time shift The researchers shifted the transdermal readings by…
A 2025 phase 1 study compared a fixed-dose CBD and hydroxychloroquine capsule with separate reference products. Thirty-six participants were randomized to three groups. The combination and the CBD reference arm each received 150 mg CBD, allowing the researchers to compare plasma exposure at the same nominal dose. The point estimate and interval tell different stories…