A report that mentions diazepam-binding inhibitor may sound like a report of diazepam in serum. The name refers to an endogenous protein, also called acyl-CoA-binding protein or ACBP. The analyte listed on the test is what determines the interpretation.
Researchers used an enzyme-linked immunosorbent assay to measure serum ACBP in 74 women with gestational diabetes and 74 gestational-age-matched pregnant controls. ACBP did not differ significantly between the two groups during pregnancy. Among the 82 women evaluated after pregnancy, the study reported higher ACBP concentrations postpartum in both groups.
This assay measured an endogenous protein in micrograms per liter. It was designed to answer a question about the protein’s relationship to gestational diabetes and postpartum physiology. To investigate diazepam exposure, a laboratory report needs to identify diazepam or the relevant metabolite and specify the matrix and analytical method. A shared word in two analyte names gives no basis for substituting one assay for the other.
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