A negative mechanistic assay narrows one concern without excluding every clinical hazard.
Researchers expressed wild-type and mutant ryanodine receptors in cultured cells. Remimazolam and propofol did not enhance the tested caffeine-associated calcium response through the receptor, including at high experimental concentrations.
The model did not reproduce an intact susceptible patient or every relevant mutation. Very high concentrations also produced calcium effects not attributed to that receptor mechanism.
Identify the cellular system and tested mutation before discussing safety implications. The findings can inform a mechanistic assessment but cannot guarantee absence of malignant hyperthermia or other anesthetic complications in an individual. Clinical susceptibility and the full drug regimen remain separate evidence.
Source: PMC7801102, supplied full-text paper. Findings are paraphrased; forensic implications are an interpretation.
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