Repeated events and a withdrawal response can strengthen suspicion without establishing a population risk.
An adult epilepsy report described recurrent low-temperature episodes after starting clobazam. Other causes were investigated, and episodes ceased during the reported months after discontinuation. The patient had experienced multiple episodes during treatment.
One case cannot determine incidence or establish that every hypothermia episode in a clobazam user is drug-caused. Evaluation of infection, endocrine conditions, environment and other medicines remains necessary.
Align temperature records and medication changes over time. A reproducible temporal pattern adds information beyond a single low reading, but is not a concentration threshold. Describe the authors’ causal suspicion alongside alternative explanations and the limits of the available follow-up.
Source: PMC4739151, supplied full-text paper. Findings are paraphrased; forensic implications are an interpretation.
Related: A Synthetic Cannabinoid Enhanced Clonazepam but Not Clobazam in One Mouse Seizure Model.