Clinical disappearance of movements does not necessarily establish electrographic seizure termination.
A study compared midazolam and levetiracetam after usual neonatal seizure treatment failed. Reported clinical control and recurrence did not differ significantly, and respiratory depression occurred in both groups. Observation was limited to a short period.
EEG and amplitude-integrated EEG were unavailable. The study therefore could not directly detect electrographic-only activity or establish long-term neurological equivalence. Nonsignificant comparisons were not proof of equal safety.
State how seizure control was measured. Sedation may reduce observable movement without answering every neurological question. The source cannot establish that all seizure activity stopped in a particular neonate or that similar short-term clinical results predict identical developmental outcomes.
Source: PMC8150062, supplied full-text paper. Findings are paraphrased; forensic implications are an interpretation.
Related: A Synthetic Cannabinoid Enhanced Clonazepam but Not Clobazam in One Mouse Seizure Model.