An antiemetic endpoint and a respiratory endpoint answer different questions.
A laparoscopic-cholecystectomy study compared palonosetron alone with palonosetron plus midazolam during anesthetic induction. The combination had lower reported postoperative nausea and vomiting and less rescue antiemetic use over the studied period.
The comparison did not establish midazolam’s effect without palonosetron or against every alternative. Similar reported side effects do not exclude uncommon harm, and no untreated placebo group was included.
State the complete combination and follow-up period. A useful nausea result cannot show that additional benzodiazepine exposure is always appropriate. Individual analysis should separately address nausea prevention, sedation, breathing, recovery and the other anesthetic drugs administered.
Source: PMC8376322, supplied full-text paper. Findings are paraphrased; forensic implications are an interpretation.
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