A case report described only modest improvement in severe restlessness during multidrug treatment. It did not establish diazepam as an effective standalone treatment for the presentation.
A young woman with chronic synthetic-cathinone use developed psychosis and marked psychomotor restlessness, diagnosed as akathisia. The symptoms were present before antipsychotic treatment at admission.
A combination including diazepam, propranolol, quetiapine, biperiden, and mirtazapine was used. The reported rating improved from eleven to seven over forty days, with substantial symptoms remaining.
The exposure history suggested a possible cathinone contribution, but multiple substances, vulnerability, evolving illness, and later medicines complicated attribution. A response under several drugs cannot isolate one component.
The case does not prove that diazepam was ineffective in every respect or that a different regimen would have produced recovery. It supports distinguishing akathisia from generic agitation and retaining the degree of residual impairment, rather than presenting any score reduction as complete treatment success.
Original analysis of the supplied journal article, identified as PMC9816890.