Recovery speed and delirium incidence need not move together.
The multicenter comparison randomized 306 patients and analyzed 272 receiving sequential remimazolam or midazolam sedation. Recovery and extubation occurred earlier with remimazolam, with less agitation, but delirium incidence did not clearly differ. A supplied correction addressed discussion citations and reference ordering.
Analgesic types were not uniform across centers, and patients differed in sedation history. Exclusion between randomization and analysis matters to appraisal. Similar RASS scores at stopping do not establish identical prior exposures or every cognitive effect.
Report the actual endpoint rather than converting faster extubation into proven delirium prevention. A patient’s ventilation duration also depends on illness and readiness decisions. The citation correction does not itself report changed clinical results; the original trial and correction should be considered together.
Source: PMC12439343, supplied full-text paper. Findings are paraphrased; forensic implications are an interpretation.
Related: Matched ICU Delirium Analysis Did Not Establish a Remimazolam Prevention Effect.
Related correction: PMC12439340 (discussion citations and reference ordering).