A numerical confidence interval that does not contain its estimate should be checked before being repeated as reliable precision.
The hysteroscopy study compared remimazolam regimens with propofol, with alfentanil part of the treatment context. Reported sedation-success proportions ranged from about 88% to 98% in the remimazolam groups. Its abstract gave an ED50 of 0.244 mg/kg together with an interval of 0.195–0.22, which does not contain that estimate.
The discrepancy should not be silently repaired by guessing the intended value. The reported ED95 interval was also broad. The selected female surgical population and combined regimen restrict transfer of these estimates to other procedures or patients.
Separate usable qualitative findings from uncertain numerical reporting. The inconsistency does not prove all observations are false, but it prevents treating the quoted interval as a verified measure of precision. Any expert calculation depending on that interval requires clarification from the underlying data or a correction; the present source alone does not provide one.
Source: PMC11018237, supplied full-text paper. Findings are paraphrased; forensic implications are an interpretation.
Related: The DREAMS End-of-Life Sedation Paper Planned Communication and Comfort Outcomes.