Fast absorption after administration does not capture every delay before treatment reaches the patient.
A route-comparison review discussed benzodiazepines for repetitive seizures and status epilepticus. It considered intravenous, intranasal, buccal and other approaches alongside caregiver skills, setting, access and formulation.
The review combined varied studies, including small trials and use of injectable preparations by alternative routes. A pharmacokinetic peak time is not identical to the time to clinical seizure control or a universal ranking across settings.
Reconstruct recognition, preparation, access, delivery and response separately. A route with rapid post-dose action may still involve logistical delay. The review cannot establish that a different route would have stopped an individual event sooner without facts about availability and actual administration.
Source: PMC8073514, supplied full-text paper. Findings are paraphrased; forensic implications are an interpretation.
Related: A Synthetic Cannabinoid Enhanced Clonazepam but Not Clobazam in One Mouse Seizure Model.