An adverse event during induction requires evaluation of all administered agents.
A report described cardiorespiratory failure during anesthesia involving several drugs. Subsequent allergy investigation produced a positive intradermal midazolam result while tests of other agents were unrevealing, supporting the authors’ suspected hypersensitivity diagnosis.
A case report cannot establish incidence, and skin-test interpretation depends on concentration, controls and clinical context. Negative tests do not make every alternative mechanism impossible.
Distinguish allergy investigation from ordinary dose-related respiratory depression. Record the sequence, physiological findings, co-medications and timing of later tests. A positive result adds evidence; it should not be replaced by the simpler claim that the last drug administered must have caused the event.
Source: PMC7874856, supplied full-text paper. Findings are paraphrased; forensic implications are an interpretation.
Related: A Synthetic Cannabinoid Enhanced Clonazepam but Not Clobazam in One Mouse Seizure Model.