A lower sedative requirement can reflect preparation and anxiety management as well as drug potency.
One hundred fifty bronchoscopy patients received either written consent information or additional multimedia information. The multimedia group reported lower state anxiety and received less midazolam, with shorter procedure duration and some measures of easier performance.
The intervention altered information rather than the pharmacology of midazolam. Results in a single procedural setting do not establish an equivalent benefit in emergencies or all patient populations.
Document preparation and baseline anxiety when evaluating a procedural dose. Dose differences cannot automatically establish tolerance, unusually high sensitivity or excessive treatment. The study shows why communication and procedural conditions belong in the reconstruction alongside medication amounts and monitoring.
Source: PMC4286843, supplied full-text paper. Findings are paraphrased; case-review implications are an interpretation.
Related: Forensic Toxicology: expert analysis and case review.