Neurotransmitter concentrations and clinical sedation are different endpoints.
A rat experiment used striatal microdialysis and chromatography after moschus, diazepam or combined exposure. Several excitatory and inhibitory amino-acid measures changed over time. The authors interpreted the pattern as potentially enhancing diazepam’s central inhibition.
Changes in selected extracellular markers do not establish human behavioral effects, a safe combination or drug penetration without the necessary direct measurements. The mixture and species are essential context.
Keep measured analytes separate from inferred mechanisms. For a human supplement co-exposure, establish the product and exposure before applying a laboratory hypothesis. The paper cannot identify the depth of sedation from a single neurotransmitter result or establish that an interaction caused a particular episode.
Source: PMC4353111, supplied full-text paper. Findings are paraphrased; case-review implications are an interpretation.
Related: Forensic Toxicology: expert analysis and case review.