Drug interactions can differ even between two benzodiazepine anticonvulsants.
In electrically induced mouse seizures, the research cannabinoid WIN 55,212-2 enhanced clonazepam protection under tested conditions but did not similarly enhance clobazam. Measured total brain drug concentrations did not show a corresponding pharmacokinetic change.
WIN 55,212-2 is not interchangeable with cannabis or CBD. A specific electrical seizure task and limited behavioral tests cannot establish human treatment benefit or comprehensive safety.
Name the exact cannabinoid and anticonvulsant. Unchanged total brain concentrations can support a pharmacodynamic hypothesis without proving the molecular mechanism. Do not transfer the result to a different cannabis product, dose, seizure disorder or individual impairment assessment.
Source: PMC4065376, supplied full-text paper. Findings are paraphrased; case-review implications are an interpretation.
Related: Forensic Toxicology: expert analysis and case review.