An oral adsorbent can interact with another drug inside the gastrointestinal tract. The amount of opportunity depends partly on how quickly the other product dissolves and how quickly drug leaves the gut by absorption.
Koya and colleagues estimated dissolution and absorption for 68 drugs at six dosing intervals. They compared the model’s estimates with earlier interaction studies for six drugs to choose thresholds, then used those thresholds to classify the predicted interaction risk for the larger set. Longer intervals increased the number of drugs classified as low risk in the model.
The modeled interval categories do not demonstrate a clinical effect for every drug in the analysis. When evaluating an individual result, identify the formulation, actual administration interval and whether the interaction was measured for the drug in question or inferred from the model.
Koya et al., modeling study of AST-120 and coadministered drugs (full text) · DOI