A healthy-volunteer model of the benzodiazepine HR7056 used two sedation measures with different estimated pharmacodynamic parameters.
Data from up to 63 Chinese healthy participants were modeled using drug concentrations, bispectral index, and the Modified Observer’s Assessment of Alertness/Sedation. A three-compartment pharmacokinetic model was selected. The reported half-maximal effect concentrations differed between the two response measures.
The endpoints capture different aspects of sedation and depend on model assumptions and sampled conditions. Simulated maintenance regimens were proposed for future study, rather than validated for every surgical or critically ill patient. Healthy participants also differ from people with organ dysfunction and interacting medicines. The study supports distinguishing concentration, estimated effect-site dynamics, and observed response. Its numerical parameters cannot establish an individual’s awareness or impairment solely from a blood level measured in another setting.
Original analysis of the supplied journal article, identified as PMC6252322.