A mixed-overdose case illustrates how substantial benzodiazepine administration can arise as treatment after poisoning.
An 18-year-old woman developed seizures after a reported large multidrug ingestion. Care included lorazepam boluses and infusion, propofol, phenobarbital, airway protection, and later cardiovascular support. A high lamotrigine concentration was measured, while subsequent EEG monitoring found no epileptiform activity during the reported interval.
A later benzodiazepine measurement could reflect administered treatment rather than a substance taken before the event. The case cannot isolate the effectiveness of lorazepam from other interventions or infer safety of the ingestion from survival without dysrhythmia. Sampling time, transfer records, infusion history, and metabolite information are therefore important in reconstructing exposure. This report describes one treated survivor and does not supply a concentration threshold for seizures or a reliable prognosis for another mixed overdose.
Original analysis of the supplied journal article, identified as PMC6980321.